Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.327


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Achr15_+_979907050.421.1e-01Click!
MEF2Dchr1_-_154737189-0.322.3e-01Click!
LOC729991-MEF2Bchr19_-_19164222-0.292.8e-01Click!
MEF2Bchr19_-_191420530.136.2e-01Click!
MEF2Cchr5_-_882147200.068.2e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_96471544 1.824 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr18_-_3209986 1.403 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr5_-_16561936 1.360 NM_019000
FAM134B
family with sequence similarity 134, member B
chr3_+_50291521 1.284 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr1_-_116184846 1.277 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_88148413 1.223 NM_198274
SMYD1
SET and MYND domain containing 1
chr18_-_33399997 1.149 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr12_-_43555607 1.134 NM_001145109
NELL2
NEL-like 2 (chicken)
chrX_-_21686079 1.060 NM_014332
SMPX
small muscle protein, X-linked
chr10_+_111755715 0.985 NM_019903
ADD3
adducin 3 (gamma)
chr3_+_129117007 0.964 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr10_-_69125932 0.921 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_-_116112684 0.920 CASQ2
calsequestrin 2 (cardiac muscle)
chr10_-_91395194 0.917 NM_148977
PANK1
pantothenate kinase 1
chr9_+_5221401 0.902 NM_002195
INSL4
insulin-like 4 (placenta)
chr15_-_68781662 0.890 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr18_-_3209846 0.876 MYOM1
myomesin 1, 185kDa
chr3_+_35658852 0.856 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_61532293 0.852 NM_031914
SYT16
synaptotagmin XVI
chr3_-_148607096 0.848 NM_032153
ZIC4
Zic family member 4
chr1_-_116112921 0.813 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr9_+_99303639 0.812 NM_003275
TMOD1
tropomodulin 1
chr1_-_116112853 0.810 CASQ2
calsequestrin 2 (cardiac muscle)
chr11_-_19180092 0.773 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr3_+_122794859 0.741 NM_016298
FBXO40
F-box protein 40
chr8_-_110730183 0.728 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr9_+_96806235 0.727 C9orf3
chromosome 9 open reading frame 3
chr11_-_123695302 0.719 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr12_-_55931172 0.709 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr7_+_94953148 0.693 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_-_115039614 0.683 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr1_-_232681471 0.681 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr5_-_137502975 0.675 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr7_+_80069439 0.660 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr13_-_50315832 0.653 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr1_+_144124547 0.637 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr11_-_31782169 0.615 PAX6
paired box 6
chr7_+_154943466 0.614 NM_001427
EN2
engrailed homeobox 2
chr10_-_14412813 0.609 NM_018027
FRMD4A
FERM domain containing 4A
chr10_-_7491204 0.609 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr11_-_18214891 0.602 NM_006512
SAA4
serum amyloid A4, constitutive
chr7_-_113346284 0.598 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr5_-_115938305 0.592 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr9_-_21218132 0.590 NM_021268
IFNA17
interferon, alpha 17
chr5_+_132433979 0.588 HSPA4
heat shock 70kDa protein 4
chr4_-_46690197 0.587 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr3_-_171070314 0.567 NM_024727
LRRC31
leucine rich repeat containing 31
chr6_+_127940011 0.565 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr7_-_15692798 0.563 NM_005924
MEOX2
mesenchyme homeobox 2
chr5_+_127016605 0.563 NM_001127385
CTXN3
cortexin 3
chr4_-_56153135 0.560 NM_152401
PDCL2
phosducin-like 2
chr7_+_93373755 0.550 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr2_-_165768798 0.544 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr19_+_17923110 0.541 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr5_-_94250357 0.538 MCTP1
multiple C2 domains, transmembrane 1
chr7_-_124217978 0.538 NM_001024603
LOC154872
hypothetical protein LOC154872
chr6_-_26216299 0.534 NM_005323
HIST1H1T
histone cluster 1, H1t
chr3_-_109730858 0.522 NM_014981
MYH15
myosin, heavy chain 15
chr10_+_18729518 0.521 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_147665783 0.516 HIST2H2BF
histone cluster 2, H2bf
chr5_+_140730014 0.515 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr9_+_5880801 0.513 NM_005511
MLANA
melan-A
chr4_+_114190233 0.509 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr12_-_242255 0.509 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr1_+_40508336 0.507 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr17_+_7495436 0.505 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr7_-_27133163 0.504 NM_153631
HOXA3
homeobox A3
chr4_+_141484046 0.500 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr16_-_70591377 0.499 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr3_+_187840842 0.492 NM_014375
FETUB
fetuin B
chr1_-_150328153 0.488 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_-_27469947 0.488 FTH1P3
ferritin, heavy polypeptide 1 pseudogene 3
chr2_-_73350103 0.484 NM_001080410
FBXO41
F-box protein 41
chr4_-_122521562 0.482 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr1_-_100416358 0.478 NM_144620
LRRC39
leucine rich repeat containing 39
chr7_-_83116414 0.478 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_-_20390601 0.477 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chrX_-_30237403 0.475 NM_000475
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr5_-_176760242 0.470 NM_001029886
PFN3
profilin 3
chr1_+_158317967 0.462 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_+_129124591 0.460 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr11_-_13474101 0.456 NM_000315
PTH
parathyroid hormone
chr1_+_92405196 0.455 NM_015237
KIAA1107
KIAA1107
chr17_+_7125702 0.454 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr3_+_120982020 0.449 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr18_-_33399601 0.448 CELF4
CUGBP, Elav-like family member 4
chr4_-_88669625 0.444 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr6_-_132980901 0.444 NM_014626
TAAR2
trace amine associated receptor 2
chr14_-_69616616 0.442 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr14_-_103058865 0.441 NM_001823
CKB
creatine kinase, brain
chr13_-_45654327 0.439 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_-_49363711 0.438 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr2_-_215956429 0.428 FN1
fibronectin 1
chr8_-_17787342 0.424 FGL1
fibrinogen-like 1
chr15_+_40438989 0.419 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr17_+_39603599 0.414 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr4_-_80548378 0.414 NM_033214
GK2
glycerol kinase 2
chr22_-_35545462 0.413 NM_002854
PVALB
parvalbumin
chrX_-_15593074 0.411 NM_020665
TMEM27
transmembrane protein 27
chr11_+_60016826 0.410 NM_001164470
NM_017716
MS4A12

membrane-spanning 4-domains, subfamily A, member 12

chr1_-_151280201 0.408 NM_006945
SPRR2D
small proline-rich protein 2D
chr1_+_42773146 0.406 NM_001080850
CCDC30
coiled-coil domain containing 30
chr16_+_14187965 0.401 MKL2
MKL/myocardin-like 2
chr9_-_21375258 0.399 NM_000605
IFNA2
interferon, alpha 2
chr7_-_83108682 0.396 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr11_+_69176391 0.395 CCND1
cyclin D1
chr9_+_21430439 0.394 NM_024013
IFNA1
interferon, alpha 1
chr8_-_42353719 0.393 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr1_-_151296611 0.392 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_+_207944807 0.391 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_+_77781903 0.390 NM_001135805
SYT1
synaptotagmin I
chr12_+_15590552 0.388 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr11_-_8921155 0.387 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr9_+_5440455 0.385 NM_014143
CD274
CD274 molecule
chr16_-_31347151 0.383 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chrX_-_128485121 0.383 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr21_+_14510336 0.382 NM_144770
RBM11
RNA binding motif protein 11
chr7_-_15692551 0.382 MEOX2
mesenchyme homeobox 2
chr14_-_30927931 0.382 NM_015473
HEATR5A
HEAT repeat containing 5A
chr8_-_26780645 0.382


chr7_+_128136347 0.377 FAM71F1
family with sequence similarity 71, member F1
chr2_+_165860528 0.376 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_+_41327449 0.375 NM_001123066
NM_001123067
NM_005910
NM_016834
NM_016835
NM_016841
MAPT





microtubule-associated protein tau





chr9_-_21156609 0.375 NM_002175
IFNA21
interferon, alpha 21
chr10_-_115413630 0.374 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr5_+_139485703 0.374 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr13_-_45654292 0.372 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_36396948 0.368 NM_003149
STAC
SH3 and cysteine rich domain
chr3_-_47909001 0.366 MAP4
microtubule-associated protein 4
chr3_-_150993299 0.365 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr5_+_140532385 0.363 NM_018940
PCDHB7
protocadherin beta 7
chr2_-_18634257 0.362 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr2_-_171796069 0.362 NM_001136554
TLK1
tousled-like kinase 1
chr9_+_99303282 0.361 NM_001166116
TMOD1
tropomodulin 1
chr9_-_99740243 0.360 NM_197978
HEMGN
hemogen
chrX_-_128485062 0.358 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr15_+_63156206 0.358 NM_001101362
KBTBD13
kelch repeat and BTB (POZ) domain containing 13
chr8_-_26780665 0.358 ADRA1A
adrenergic, alpha-1A-, receptor
chr19_-_51856129 0.358 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr6_+_46822657 0.358 NM_001162435
LOC100287718
ankyrin repeat domain containing gene
chr13_+_42046182 0.358 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_-_128485134 0.356 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr11_+_128751044 0.356 NM_003658
BARX2
BARX homeobox 2
chr22_+_40372957 0.355 XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr2_-_179623030 0.353 NM_173648
CCDC141
coiled-coil domain containing 141
chr12_+_105501161 0.352 NM_213594
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr3_+_171560104 0.352 NM_001145097
SKIL
SKI-like oncogene
chr22_+_20899155 0.350


chr3_+_23904086 0.350 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr2_-_121964373 0.344 CLASP1
cytoplasmic linker associated protein 1
chr12_+_53178834 0.344 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr21_+_38550739 0.341 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_33268177 0.340 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr4_-_187114407 0.338 SORBS2
sorbin and SH3 domain containing 2
chr6_-_76259976 0.337 NM_015687
FILIP1
filamin A interacting protein 1
chr13_-_45654296 0.337 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_161701711 0.334 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr1_+_154478574 0.334 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr2_-_224574860 0.332 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_-_130021845 0.331 NM_052933
TSGA13
testis specific, 13
chr19_+_17723285 0.330 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr9_-_21229975 0.330 NM_002172
IFNA14
interferon, alpha 14
chr4_+_111053488 0.329 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr12_+_8866416 0.328 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr1_-_155336223 0.327 NM_001004341
ETV3L
ets variant 3-like
chr1_-_148959945 0.327 NM_032132
HORMAD1
HORMA domain containing 1
chr22_-_16060485 0.326 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr17_-_70367479 0.325 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr15_-_48192804 0.324 ATP8B4
ATPase, class I, type 8B, member 4
chr8_+_104900591 0.322 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr4_+_37569093 0.321 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr10_+_83627422 0.320 NM_001165973
NRG3
neuregulin 3
chr2_+_204509698 0.317 NM_012092
ICOS
inducible T-cell co-stimulator
chr12_-_68291208 0.317 NM_201550
LRRC10
leucine rich repeat containing 10
chr12_+_47205681 0.316 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr6_-_130578110 0.315 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr4_+_15038726 0.315 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr21_-_18697829 0.315 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr19_-_55524445 0.315 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr5_-_35974493 0.314 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr5_-_37220702 0.313 C5orf42
chromosome 5 open reading frame 42
chr3_-_150533948 0.312 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_-_55358091 0.309 NM_152358
IZUMO2
IZUMO family member 2
chr18_-_3864252 0.309 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr13_-_97916768 0.309 STK24
serine/threonine kinase 24
chr3_-_46224791 0.308 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr6_-_41811916 0.307 NM_001167827
TFEB
transcription factor EB
chr7_+_99263571 0.307 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr10_+_80743769 0.305 ZMIZ1
zinc finger, MIZ-type containing 1
chr12_-_10215942 0.305 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_+_188197029 0.304


chr1_-_181540631 0.302 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr13_-_35327798 0.302 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr15_+_38318528 0.301 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr9_-_21207303 0.300 NM_002173
IFNA16
interferon, alpha 16
chr14_-_103058568 0.299 CKB
creatine kinase, brain
chr2_-_200038055 0.298 NM_001172517
SATB2
SATB homeobox 2
chr8_-_23768242 0.297 NM_003155
STC1
stanniocalcin 1
chr1_-_151333624 0.296 NM_001024209
SPRR2E
small proline-rich protein 2E
chr10_-_75080784 0.295 NM_024875
SYNPO2L
synaptopodin 2-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 3.69e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.57 2.03e-04 GO:0044421 extracellular region part
1.60 1.25e-03 GO:0005615 extracellular space
1.34 1.98e-03 GO:0005576 extracellular region
9.18 2.06e-02 GO:0005577 fibrinogen complex

Nothing significant found in function category.